Botulinum Toxin

Botulinum Toxin Type A (BTX100 – 100 IU) by GX Peptide Supply is a purified neurotoxin complex derived from Clostridium botulinum. As one of the most potent biological substances known to science, BoNT-A is a critical tool in research involving synaptic vesicle fusion, acetylcholine release, and localized muscle denervation. This product is specifically engineered for high-precision studies in movement disorders and neurological signaling pathways.

Key Product Features:

• Mechanism of Action: Selectively cleaves the SNAP-25 protein, a vital component of the SNARE complex, effectively blocking the release of acetylcholine at the neuromuscular junction.

• Precision Purity: Purified via a series of dialyses and acid precipitations to provide a stable complex consisting of the 150 kDa neurotoxin and associated accessory proteins.

• Potency Consistency: Standardized to 100 Units (IU) per vial, allowing researchers to maintain strict control over experimental dosing and replication.

• Stabilized Formulation: Vacuum-dried and typically contains a stabilizer such as human albumin to maintain the structural integrity of the neurotoxin during transport and storage.

Research Applications:

• Investigation of focal spasticity and muscle hypertonicity models.

• Studies on chronic pain modulation and neurotransmitter activity.

• Research into synaptic vesicle recycling and cellular intoxication pathways.

• Laboratory analysis of bladder dysfunction and detrusor overactivity mechanisms.

Storage & Safety Protocols:

• Temperature: Research vials must be kept refrigerated at 2°C to 8°C (36°F to 46°F) to prevent denaturation.

• Reconstitution: Use only sterile, unpreserved 0.9% sodium chloride (saline) for reconstitution; avoid vigorous shaking to prevent mechanical degradation of the toxin.

• Deactivation: All waste and spills must be treated with a 10% bleach solution for at least 30 minutes or autoclaved where legally permissible.